Congenital diffuse bronchio-alveoliectasis: a variant of congenital cystic disease of the lungs.

CHEST, VOL. 61, NO. 5, MAY 1972 ulcerations of the larynx. Recently, Caillard et al described a 34-year-old man who, after three years of chemotherapy for chronic Iymphocytic leukemia, developed a subglottic lymphomatous infiltrate. The tumor rapidly shrank in response to local radiotherapy. Localized lymphomas at this site are a!so rare. In 5,319 consecutive patients with malignant lymphoma seen at the Mayo Clinic, DeSanto and Weiland4 found only nine who had primary laryngeal tumor-six with lymphosarcoma, three of reticulum sarcoma. Climie et a!5 have described a unique lymphoid hamartoma arising in the pvriform sinus. Pathologically, it was characterized by prominent lymph follicles, but absent lymph sinuses. Al-Saleem and associates6 reviewed five cases in the world literature of tumor-like hyperplasia of the reticuloendothelial system localized in the larynx. The same authors reported an additional patient with supraglottic pseudolymphoma. None of the six patients had systemic blood abnormality or regional node involvement. Studies of disseminated lymphomas have rarely shown laryngeal involvement. Sugarbaker and Craver7 found the larynx affected in 0.5 percent of patients with hematogenous or lyrnphomatous spread of lymphosarcoma. Shilling, et als autopsied 19 patients who died of malignant lymphoma or leukemia. Sixty percent of these patients had histologic involvement of the larynx. Cranulocytic leukemia was the usual cause of clinically apparent tumor characterized by stridor. The authors associated these larger tumors with the hemorrhage and necrosis more common in granulocytic infiltrates.None of the three patients with lyrnphocytic leukemia had more than microscopic involvement.